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Is it Safe to Take Spironolactone and Chiral Balance D-chiro-inositol? |
Spironolactone (brand names: aldactone, spiractin etc.) is an aldosterone antagonist and moderates responsiveness to androgens as well. It is often prescribed to manage some of the symptoms of PCOS related to hyperandrogenism, such as hirsutism, androgenic alopecia and acne. It is a potent anti-diuretic. Its anti-androgenic effects are secondary and result from competitively binding to androgen receptors thereby preventing testosterone and dihydrotestosterone from acting. It has numerous side-effects.
D-chiro-inositol (DCI) addresses hyperandrogenism is an entirely different way. The insulin resistance commonly associated with PCOS is the cause of hyperandrogenism, and DCI address this at its root. By restoring insulin sensitivity, androgen levels come down to within normal range and symptoms diminish.
Spironolactone addresses the symptoms of elevated testosterone and DCI addresses its etiology. Their very distinct mechanisms suggest little likelihood for interaction. Consequently, DCI may obviate spironolactone altogether.
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18 |
| Posted
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25-6-2009 |
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