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Is it Safe to Take TZD drugs and Chiral Balance D-Chiro-inositol? |
Thiazolidinediones, such as Actos and Avandia, are sometimes used to address the insulin resistance commonly associated with PCOS. Called TZD drugs or glitazones for short, these drugs are a second-line therapy and are typically tried after Metformin. Avandia and Metformin are sometimes prescribed simultaneously as the combination drug Avandamet. They act by binding to PPARs and modulating transcription of insulin-sensitive genes related to metabolism. In a sense, these drugs circumvent the steps of insulin signal transduction that are dysfunctional in insulin resistance. TZD drugs have numerous side-effects.
D-chiro-inositol (DCI) addresses insulin resistance in a different way, by ensuring the body has sufficient DCI to respond to insulin normally, as there is some evidence that women with PCOS are deficient in DCI.
DCI addresses the putative cause of insulin resistance whereas TZD drugs address the symptoms. DCI has no known side effects and consequently may obviate a TZD drug entirely.
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17 |
| Posted
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25-6-2009 |
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