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Tri Sense

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Insulin Resistance Supplements

Five natural products to help control glucose.

Our newly-reformulated Tri Sense brings together five natural insulin sensitizers: cinnamon extract, green tea extract, chromium, manganese, and vitamin D3 as a measure for blood sugar regulation for PCOS.

Tri Sense is a great complement to DCI or myo-inositol therapy for women with PCOS, these glucose control supplements can be helpful for anyone with insulin resistance issues such as metabolic syndrome or diabetes.

This formula uses only leucine, an essential amino acid, as a flow agent. There are no other inactive ingredients, besides the vegetable capsule. No preservatives, no magnesium stearate, no artificial colors or flavors.

Active Ingredients

Cinnamon Bark Extract (Cinnulin PF
®) — 125 mg

A 20:1 cinnamon extract with no coumarin.

Raw cinnamon is rather bulky and contains coumarin, a naturally occurring substance that may be harmful to certain sensitive individuals. Using Cinnulin PF® allows us to reduce the bulk of the capsules (which allows for once daily dosing) while removing all the coumarin from our formula.

Numerous human studies have shown beneficial effects of cinnamon and extracts of cinnamon on glucose, insulin, insulin sensitivity, lipids, blood pressure, and lean body mass in subjects with metabolic syndrome, type 2 diabetes, and PCOS. A new research study suggests the mechanism of action is due to cinnamaldehyde, which induces thermogenesis in adipocytes (med speak for fat cells burning fat).

Green Tea Leaf Extract — 360 mg

90% Polyphenols, including 162 mg EGCG (epigallocatechin gallate)

Green tea contains powerful anti-oxidants, which have been shown to be beneficial in a multitude of ways. Most notably for women with PCOS, polyphenols in green tea have been shown to reduce fasting glucose, insulin, and hemoglobin A1c levels, and consumption of tea has been shown to reduce the risk of type 2 diabetes.

Our Tri Sense formula contains 360 milligrams of green tea extract, which is equivalent to about 4 cups of green tea, in terms of the content of polyphenols (including epigallocatechin gallate, or EGCG).

Please be aware that green tea extract contains a small amount of caffeine, approximately 4 milligrams per capsule. For comparison, a cup of green tea contains 24-45 milligrams of caffeine; a cup of brewed coffee contains 100-200 milligrams.

Chromium Polynicotinate (ChromeMate®) — 1000 mcg

Chromium is an essential trace element. Supplementation has been shown to have beneficial effects in people with varying degrees of glucose intolerance ranging from mild glucose intolerance to PCOS to type 2 diabetes.

Chromium potentiates the action of insulin, and helps to lower overall cholesterol while increasing levels of "good" cholesterol.

Manganese Citrate — 2 mg

An in vivo animal study suggests that the combination of manganese and DCI is much more effective than either alone in reducing glucose levels. In the study, test subjects' blood glucose levels were reduced (over two hours) by 21% with the administration of DCI. With the addition of manganese, the reduction was increased to 47%.

Please be aware that The National Institute of Health advises against more than 11 milligrams of manganese per day for adults. Most daily multivitamins contain about 2 milligrams. If you are getting manganese from other supplements as well, do the math and make sure you are within the recommended range.

Vitamin D3 (Cholecalciferol) — 1000 IU

Vitamin D deficiency is common in women with PCOS, and is associated with metabolic risk factors such as insulin resistance and low "good" cholesterol levels.

Accumulating evidence suggests the role of vitamin D in the pathogenesis of insulin resistance, including several vitamin D-related gene polymorphisms and vitamin D-related metabolic and immune pathways. Supplementation of vitamin D may provide for suitable management and act to ameliorate insulin resistance.

Resources/Further Reading


Review of: Systematic Review/Meta-analysis Finds Cinnamon Significantly Lowers Total Cholesterol and Triglycerides, but Not Low-Density Lipoprotein or High-Density Lipoprotein Cholesterol

Original research:
Maierean SM, Serban MC, Sahebkar A, et al.; on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis. J Clin Lipidol. November-December 2017;11(6):1393-1406.

Kort DH, Lobo RA. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol. 2014;211(5):487.e1-6. http://www.ncbi.nlm.nih.gov/pubmed/24813595

Khan A, Safdar M, Ali khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26(12):3215-8. http://www.ncbi.nlm.nih.gov/pubmed/24813595

Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 2010;4(3):685-93. http://www.ncbi.nlm.nih.gov/pubmed/20513336

Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med. 2013;11(5):452-9. http://www.ncbi.nlm.nih.gov/pubmed/24019277

Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45-53. http://www.ncbi.nlm.nih.gov/pubmed/18500972

Jiang J, Emont MP, Jun H, et al. Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. Metab Clin Exp. 2017;77:58-64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685898/

Green Tea

Liu K, Zhou R, Wang B, et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr. 2013;98(2):340-8. http://www.ncbi.nlm.nih.gov/pubmed/23803878

Yang J, Mao QX, Xu HX, Ma X, Zeng CY. Tea consumption and risk of type 2 diabetes mellitus: a systematic review and meta-analysis update. BMJ Open. 2014;4(7):e005632. http://www.ncbi.nlm.nih.gov/pubmed/25052177

Anderson RA, Polansky MM. Tea enhances insulin activity. J Agric Food Chem. 2002;50(24):7182-6. http://www.ncbi.nlm.nih.gov/pubmed/12428980

Rizvi SI, Zaid MA, Anis R, Mishra N. Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. Clin Exp Pharmacol Physiol. 2005;32(1-2):70-5. http://www.ncbi.nlm.nih.gov/pubmed/15730438


Lydic ML, Mcnurlan M, Bembo S, Mitchell L, Komaroff E, Gelato M. Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome. Fertil Steril. 2006;86(1):243-6. http://www.ncbi.nlm.nih.gov/pubmed/16730719

Mertz W. Chromium in human nutrition: a review. J Nutr. 1993;123(4):626-33. http://www.ncbi.nlm.nih.gov/pubmed/8463863

A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14. http://www.ncbi.nlm.nih.gov/pubmed/15208835


Fonteles MC, Almeida MQ, Larner J. Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats. Horm Metab Res. 2000;32(4):129-32. http://www.ncbi.nlm.nih.gov/pubmed/16730719

Vitamin D

Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012;2012:634195. http://www.ncbi.nlm.nih.gov/pubmed/22988423

Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metab Clin Exp. 2011;60(10):1475-81. http://www.ncbi.nlm.nih.gov/pubmed/21550088

Kotsa K, Yavropoulou MP, Anastasiou O, Yovos JG. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril. 2009;92(3):1053-8. http://www.ncbi.nlm.nih.gov/pubmed/18930208

These statements have not been reviewed by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.